| ACLIMAGE | Estimating the acute impact of competing mental imagery on craving in alcohol use disorder. | NCT04958655 | Pending |
| ACTfR | ACT for Recovery | ISRCTN68540929 | Published |
| ACTIB | Assessing Cognitive behavioural Therapy in Irritable Bowel | ISRCTN44427879 | Published |
| ACTMUS | Acceptance and Commitment Therapy for Muscle Disease | NCT02810028 | Published |
| ADAPT | The role of anti-IgE (omalizumab) in the management of severe recalcitrant paediatric atopic eczema | ISRCTN15090567 | Published |
| ADEPT | Optimising psychological treatment for Anxiety DisordErs in Pregnancy: a feasibility treatment trial | ISRCTN81203286 | Published |
| ADeSS | The Antidepressant Advisor: A decision support system for UK primary care – a feasibility study | NCT03628027 | Published |
| ADVANCE | Feasibility of adapting and delivering the ADVANCE technology enabled intervention to reduce intimate partner abuse by men receiving substance use treatment | ISRCTN66619273 | Pending |
| ADVANCE feasibility | Feasibility and acceptability of a randomised controlled trial of an integrated group intervention to reduce intimate partner violence perpetration among men receiving treatment for substance use | ISRCTN79435190 | Published |
| AerosureCF | A short – term comparative study of Aerosure for airway clearance in patients with cystic fibrosis | NCT01923753 | Pending |
| AerosureCOPD | Does high-frequency airflow oscillation, delivered using Aerosure, increase exercise capacity in severe chronic obstructive pulmonary disease? | NCT02007590 | Pending |
| AMBITION | Mindfulness-based crisis interventions (MBCI) for psychosis within acute inpatient psychiatric settings: a feasibility randomised controlled trial | ISRCTN37625384 | Published |
| APIPPRA | Arthritis Prevention In the Pre-clinical Phase of RA with Abatacept (APIPPRA) | ISRCTN46017566 | Pending |
| AneurysmCare | Aneurysm Care Pilot Study | ISRCTN65746249 | Published |
| APRICOT | Treatment of pustular psoriasis with the IL-1 receptor antagonist anakinra: a randomised, placebo controlled trial and associated mechanistic studies | 2015-003600-23 | Pending |
| ARC | The Addiction Recovery Clinic (ARC): personalised behavioural intervention for opioid use disorder | ISRCTN69313751 | Published |
| ASCOT | A phase 3 multi-center double masked randomised controlled trial of adjunctive intraocular and periocular steroid (triamcinolone acetonide) versus standard treatment in eyes undergoing viteroretinal surgery for open globe trauma | ISRCTN30012492 | Pending |
| ASPI | Anxiety Symptoms Prevention Investigation (ASPI): Transmission of anxiety from parent to child ? investigating cognitive-behavioural processes, developing and piloting a brief preventative intervention | ISRCTN57199411 | Published |
| ATLANTIS | AnTiconvuLsant AugmeNtation Trial In Schizophrenia: a randomised, pragmatic double-blind, placebo-controlled trial to assess the effectiveness of valproate augmentation of antipsychotic treatment in patients with residual psychotic symptoms | ISRCTN77257074 | Pending |
| ATOM | Atomoxetine for attention deficit hyperactivity disorder (ADHD) in children with special educational needs | ISRCTN25691213 | No publication |
| AVATAR | Reducing the frequency and severity of auditory hallucinations: a randomised clinical trial of a novel Audio-Visual Assisted Therapy Aid for Refractory auditory hallucinations (AVATAR) compared to supportive counselling | ISRCTN65314790 | Published |
| AWARE | Promoting mental health and wellbeing in schools: examining Youth Aware of Mental Health (YAM) and the Mental Health & High School Curriculum Guide (The Guide) in English secondary schools | ISRCTN17631228 | Pending |
| BalancingACT | Balancing ACT: Evaluating the effectiveness of psychoeducation and Acceptance and Commitment Therapy (ACT) groups for people with bipolar disorder | ISRCTN73327972 | Pending |
| BAP-EFL | Feasibility Randomised Controlled Trial of Being a Parent- Enjoying Family Life: a specialised intervention for parents with significant emotional and interpersonal needs. | ISRCTN10950727 | Pending |
| BARILIFESTYLE | Evaluation of the effect of a post-surgery lifestyle intervention compared to usual care upon post-surgery weight loss and changes in body composition, physical activity levels and health-related quality of life in the first year following bariatric surgery | NCT03214471 | Published |
| BIORA-PAIN | Comparison of abatacept with tumor necrosis factor inhibitors in the treatment of rheumatoid arthritis pain: A phase IV trial | 2019-004468-23 | Pending |
| BEMIND | A comparison to two types of group behaviour therapy for obsessive compulsive disorder: A pilot randomised controlled trial of behaviour therapy and mindfulness-based behaviour therapy for OCD | ISRCTN52684820 | Published |
| BESST | Early intervention for depression and anxiety in 16–18-year-olds: a multi-centre, cluster randomised control trial of a self-referral psychological stress workshop programme in schools (BESST study – Brief Educational workshops in Secondary Schools Trial) | ISRCTN90912799 | Pending |
| BISCORT | Does a breathlessness intervention service (‘CBIS’) reduce stress significantly more than usual care in breathless patients with advanced non-malignant disease and their carers? A phase II feasibility study | ISRCTN70836126 | Pending |
| BREATHLESSNESS | Development of King’s College Hospital Breathlessness Service | NCT01165034 | Published |
| BreathePlus Feasibility | Breathe Plus: Feasibility trial of a comprehensive geriatric assessment for people with COPD and frailty attending pulmonary rehabilitation | ISRCTN13051922 | Pending |
| BReF | Cognitive Behavioural Therapy (CBT) for Renal Fatigue (BReF): A feasibility pilot randomised-controlled trial of CBT for the management of fatigue in haemodialysis (HD) patients | ISRCTN91238019 | Published |
| CACTUS | A parallel arm, biomarker driven, phase II feasibility trial to determine the role of circulating tumour DNA in guiding a switch between targeted therapy and immune therapy in patients with advanced cutaneous melanoma | NCT03808441 | Pending |
| CADMUS | Multi-parametric Ultrasound targeted biopsies compared to Multiparametric MRI targeted biopsies in the diagnosis of clinically significant prostate cancer | NCT02712684 | Published |
| CALLME | Care Augmentation by Location-Linked Messaging | ISRCTN71271888 | Pending |
| CANWALK | A study to assess the acceptability and feasibility of a walking intervention for people with recurrent or metastatic cancer | ISRCTN42072606 | Published |
| CAREER | CAReer management to improve Education, Employment and Retention for people with anxiety and depression | ISRCTN17767032 | Published |
| CASA-AF | Catheter Ablation vs. Thoracoscopic Surgical Ablation in Long-Standing Persistent Atrial Fibrillation | ISRCTN18250790 | Published |
| CASIS | A randomised pragmatic trial comparing the cost effectiveness of supplementing standard care with an intervention for carers (Carers Assessment, Skills and Information Sharing [CASIS]) of people with eating disorders | ISRCTN06149665 | Published |
| CBDVR2 | The effect of CBD on paranoid cognitions in humans | ISRCTN11082858 | Pending |
| CBM-pa | Cognitive Bias Modification for Paranoia | ISRCTN90749868 | Published |
| CIAOII | Randomised controlled trial of the short term effects of OROS-methylphenidate on ADHD symptoms and behavioural outcomes in young male prisoners with attention deficit hyperactivity disorder | ISRCTN16827947 | Published |
| CIIC | Clinical Study of Imagery-based Coping for Cocaine Use Disorder | NCT03656653 | Published |
| CLARITY | Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial | 013-003272-12 | Published |
| CLASSIC | Can ‘self-confidence workshops’ for depression help the implementation of the NICE Guidelines? | ISRCTN26634837 | Published |
| CLEOPATRA | The clinical efficacy and safety of light-masks at preventing dark adaptation in the treatment of early diabetic macular oedema: A Multicentre Phase III Randomised Controlled Single-Masked Clinical trial | ISRCTN85596558 | Published |
| CLIP | Pharmacokinetic study of a novel lipid formulation of cannabidiol (CBD) | ISRCTN18067579 | Pending |
| CODES | COgnitive behavioural therapy vs standardised medical care for adults with Dissociative non-Epileptic Seizures: A multicentre randomised controlled trial | ISRCTN05681227 | Published |
| CONMAN | Contingency management targeting increased completion of hepatitis B (Hep B) vaccination amongst people in treatment for heroin dependence | ISRCTN72794493 | Published |
| CONVINCE | A study to assess the feasibility and patient acceptability of a randomised, crossover design to compare virtual vs conventional chromoendoscopy for the detection of dysplasia in colitis. | NCT02543021 | Published |
| COPe | EFFIP (E-support for Families and Friends of Individuals affected by Psychosis): A randomised controlled trial of a co-produced online intervention for carers | ISRCTN89563420 | Pending |
| COPE | The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study | N/A | Published |
| CORAL | COnceal or ReveAL | NCT01379014 | Published |
| CRAVING | Pilot Feasibility Study of Cognitive Control in Cocaine Dependence | ISRCTN16462783 | Published |
| CRIB | Cognitive Remediation in Bipolar disorder: a feasibility study | ISRCTN32290525 | Published |
| CRIMSON | CRIMSON Study: Randomised controlled trial (RCT) of Joint Crisis Plans to reduce compulsory treatment of people with psychosis | ISRCTN11501328 | Published |
| CRISP | Critical time intervention for severely mentally ill released prisoners | ISRCTN98067793 | Published |
| CRUNCH | Development of a randomized controlled trial to increase cereal fibre intake to reduce insulin resistance in children. | ISRCTN33260236 | Published |
| CTAR-SWIFT | Chin Tuck Against Resistance with Feedback: Swallowing Rehabilitation in Frail Older People – A feasibility study | ISRCTN12813363 | Pending |
| CUES | Coping with Unusual Experiences in Children Study | ISRCTN13766770 | Published |
| CUESPLUS | Coping with Unusual ExperienceS for 12-18 (CUES+) | ISRCTN21802136 | Pending |
| DAISIES | A Randomised Controlled Multi-Centre Open-Label Parallel Group Non-Inferiority Trial of the Clinical Effectiveness, Acceptability and Cost-Effectiveness of a ‘Stepping into Day Treatment’ Approach versus Inpatient Treatment as Usual for Anorexia Nervosa in Adult Specialist Eating Disorder Services (DAISIES Trial) | ISRCTN10166784 | Pending |
| DATES | Diabetes And Telecommunications Study to support self-management for people with type 2 diabetes: a randomized controlled trial(The DATES trial) | ISRCTN10342151 | Pending |
| DAWN | Depression: a trial of antenatal guided self help for women | ISRCTN83768230 | Published |
| DFEND | A randomised, double-blind, placebo-controlled, parallel-group trial of Vitamin D supplementation compared to placebo in people presenting with their First Episode of psychosis Neuroprotection Design (DFEND) | 2014-002639-32 | Published |
| Diabetes StopWatch | Motivational Instant Messaging and E-diabetes Prevention Programme for High Risk of Type 2 Diabetes | NCT02919397 | Published |
| DIMES | Insulin intervention development for people with type 2 diabetes | ISRCTN13339678 | Published |
| DISCOVER | Early intervention for depression and anxiety in 16-18 year olds: a feasibility trial of open-access psychological workshops in schools | ISRCTN88636606 | Published |
| DISKO | The Effect of Denosumab on Pain and Bone Marrow Lesions in Symptomatic Knee Osteoarthritis: A Randomised Double Blind Placebo Controlled Clinical Trial | ISRCTN96920058 | Pending |
| ECHO | Expert Carers Helping Others | ISRCTN83003225 | Published |
| ECLIPSE | ECLIPSE Study 9: Building resilience and recovery through enhancing cognition and quality | ISRCTN14678860 | Pending |
| EFFECT-DEP | The EFFECT-Dep study: Enhancing the effectiveness of electroconvulsive therapy in severe depression | ISRCTN23577151 | Published |
| EMPIRIKAL | An Investigation into the Efficacy of Mirococept (APT070) for Preventing Ischaemia-Reperfusion Injury in the Kidney ALlograft (EMPIRIKAL) | ISRCTN49958194 | Published |
| EN-PENS | A randomised patient-assessor blinded sham controlled trial of External non-invasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial) | ISRCTN53432663 | Published |
| EPACS | Early prolonged ambulatory heart monitoring in patients with stroke | ISRCTN50253271 | Published |
| EpAID | Improving outcomes in adults with epilepsy and intellectual disability: a cluster randomised controlled trial of nurse-led epilepsy management (EpAID) | ISRCTN96895428 | Published |
| EPATH | Randomised controlled trial of an app-based digital intervention to support breast cancer survivors prescribed hormone therapy | ISRCTN51581601 | Pending |
| EPIC-HFT | Exacerbation Prevention in COPD – Effect of Home High-Flow Therapy vs. Usual Care on Hospital Readmission or Death After an Acute Chronic Obstructive Pulmonary Disease (COPD) Exacerbation: a UK-Based Multicentre Randomised Clinical Trial | ISRCTN89405844 | Pending |
| EQUIPP | A randomized controlled trial of quetiapine for psychosis in Parkinson’s disease. | ISRCTN74681449 | Published |
| ERTTP | A phase IV, prospective, randomised single-blind UK multicentre, non-inferiority trial of low-dose versus standard dose rituximab for prevention of relapses in acquired TTP | 2017-001117-86 | Pending |
| ESibling | Exploratory randomised controlled trial of an online multi-component psychoeducational intervention for siblings of individuals with first episode psychosis | ISRCTN01416694 | Published |
| ESMI MBU | The Effectiveness and cost-effectivenesS of Mother and Baby Units versus general psychiatric Inpatient wards and Crisis Resolution Team services | N/A | Published |
| EXPO | Extended-Release Pharmacotherapy for Opioid Use Disorder | 2018-004460-63 | Pending |
| EXPRESD | A randomised controlled trial to assess the feasibility and efficacy of using an expressive writing intervention with patients on haemodialysis | ISRCTN19773253 | Published |
| FABULAS | Feasibility study of radiofrequency endoscopic ablation, with ultrasound guidance, as a non-surgical, adrenal sparing treatment for aldosterone-producing adenomas | ISRCTN86062633 | Pending |
| FERARO | A prospective, randomised placebo controlled feasibility trial of Faecal microbiota Transplant to ERadicate gastrointestinal carriage of Antibiotic Resistant Organisms | ISRCTN34467677 | Pending |
| FEVER | Influenza vaccine in nursing homes – why doesn’t it work? | ISRCTN28553709 | Published |
| FINCH | FInCH Study: A randomised feasibility study comparing fluoride interventions to prevent dental decay in older people in care homes. | 2017-002248-34 | Pending |
| FORSUS | Comparison of the effectiveness of the Twin Block and FORSUS functional appliance for the treatment of Class II division 1 malocclusion patients | ISRCTN80447398 | No publication |
| FRAMEFIT | Frame Fit. A randomised controlled trial to determine the acceptability, safety and efficacy of a falls prevention exercise programme for walking frame users. | ISRCTN57645734 | Pending |
| GETSET | Graded Exercise Therapy guided SElf-help Treatment (GETSET) for patients with chronic fatigue syndrome/myalgic encephalomyelitis: a randomised controlled trial in secondary care | ISRCTN22975026 | Published |
| GLIDE | Gastric Band and Liraglutide Intervention in Diabetes Evolution – A Randomised Double-Blind Placebo-Controlled Trial | ISRCTN10551314 | Pending |
| GOALS | A Randomised Controlled Trial of a Brief CBT Intervention to Promote Recovery in Psychosis | ISRCTN73188383 | Published |
| GOLEVEL | Study of the Golimumab Exposure-Response Relationship using Serum Trough Levels | NCT03124121 | Published |
| GOMARK | Investigating Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine | NCT04977674 | Pending |
| HFPRCT | Helping Families: Psychoeducational Intervention for Parents with Personality Disorders | ISRCTN14573230 | Published |
| HIIT in SMI | “Is the use of high intensity interval training (HIIT) feasible and acceptable amongst inpatients with Severe Mental Illness (SMI)?” A Pilot Study. | NCT03959735 | Pending |
| HINT | Can exercise reduce disability in peripheral neuropathy? | ISRCTN13311697 | Pending |
| HMBICU | A study to investigate the effect of β-hydroxy-β-methylbutyrate (HMB) on skeletal muscle wasting in early critical illness | NCT03464708 | Pending |
| HOTKID | The Hypertension Optimal Treatment in Children with Chronic Kidney Disease study: the HOT-KID study – a randomised trial to compare effects of aggressive versus standard targets in blood pressure on target organ damage in children with CKD | ISRCTN25006406 | Published |
| HSEN | A double-blind, placebo-controlled trial of methylphenidate in children with hyperkinetic disorder and moderate-severe learning disabilities | ISRCTN68384912 | Published |
| HTA-SADD | HTA Study of Antidepressants for Depression in Dementia: A definitive multi-centre pragmatic randomised controlled double-blind trial of the clinical and cost effectiveness of mirtazapine and sertraline versus placebo for the treatment of depression in dementia presenting in secondary care | ISRCTN88882979 | Published |
| I AM HEALTH | Autism spectrum treatment and resilience (ASTAR) | ISRCTN91411078 | Published |
| IMAGINE | A brief early intervention for adolescent depression that targets emotional memories: a feasibility randomised controlled trial | ISRCTN85369879 | Published |
| iMarkHD | iMarkHD: Longitudinal Adaptive Study of Molecular Pathology and Neuronal Networks in Huntington’s Disease Gene Expansion Carriers (HDGECs) and Healthy Controls using Positron Emission Tomography (PET) and Multi-modal Magnetic Resonance Imaging (MRI) | N/A | Pending |
| IMPACT | Improving physical health and reducing substance use in psychosis | ISRCTN58667926 | Published |
| IMPROVECARE | A study to assess the acceptability and feasibility of a walking intervention for people with recurrent or metastatic cancer | ISRCTN36040085 | Published |
| INCVD | Imaging cerebral neuroinflammation in acute and chronic cerebrovascular disease: a predictor of outcome and biomarker for guiding treatment (IN-CVD) | ISRCTN13797354 | No publication |
| INSPIRE | Promoting mental wellbeing in schools using mindfulness, relaxation and strategies for safety and wellbeing | ISRCTN16386254 | Pending |
| InterMuscle | A Phase 2 Pilot Physiological Randomised Clinical Trial to Investigate the Effect of Intermittent versus Continuous Enteral Nutrition on Muscle Wasting in Critical Illness | NCT02358512 | Published |
| INTERSTAARS | Attention Control Training for Infants at Risk for ADHD | ISRCTN37683928 | Pending |
| INVEST | INVEST: A feasibility study of psychologically informed vestibular rehabilitation for chronic dizziness | ISRCTN10420559 | Published |
| IPS-AD | Effectiveness and cost-effectiveness of employment support during treatment for drug and alcohol dependence: the Individual Placement and Support for Alcohol and Drug dependence (IPS-AD) trial | ISRCTN24159790 | Pending |
| IPTG01 | An antimicrobial cream for the treatment of impetigo | 2008-000036-41 | Published |
| IRIS | Inflammatory Response In Schizophrenia (IRIS) | NCT03093064 | Pending |
| Iron & Muscle | Multicentre prospective double-blind randomised controlled trial of the effect of intravenous iron supplementation with or without exercise training in iron-deficient, but not anaemic, patients with chronic kidney disease on exercise capacity, physical function, fatigue and skeletal muscle metabolism. | 2018-000844-25 | Published |
| IRTC | Short-term integrated rehabilitation for people with thoracic cancer: A feasibility trial | ISRCTN92666109 | Published |
| JOSHUA | JOSHUA: a pilot randomised controlled trial of joint crisis plans for people who self harm | ISRCTN12440268 | Published |
| LAST | Effect of Lixisenatide on arterial stiffness in patients with diabetic nephropathy | 2016-001758-17 | Pending |
| LEAVO | A Multicentre Phase III Double-masked Randomised Controlled Non-Inferiority Trial comparing the clinical and cost effectiveness of intravitreal therapy with ranibizumab (Lucentis) vs aflibercept (Eylea) vs bevacizumab (Avastin) for Macular Oedema due to Central Retinal Vein Occlusion (CRVO) | ISRCTN13623634 | Published |
| LIBA | Lipid Ibuprofen versus standard of care for acute hypoxemic respiratory failure due to COVID-19: A multicentre, open label Randomised Controlled Trial | 2020-001203-16 | Pending |
| LICALS | Lithium Carbonate for patients with Amyotrophic Lateral Sclerosis | ISRCTN83178718 | Published |
| LIPS | Low dose intravenous immunoglobulin treatment for complex regional pain syndrome | 2012-000058-73 | Published |
| LITE | Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans | NCT02949492 | Published |
| LivDem | A Pilot Randomised Controlled trial to compare changes in quality of life for participants with early diagnosis dementia who attend a “Living well with dementia” group compared to waiting-list control | ISRCTN25079950 | Published |
| LoTO CASA-AF | Long Term Outcomes in Long Standing Persistent Atrial Fibrillation Comparing Catheter Ablation & Thoracoscopic Surgical Ablation | NCT04280042 | Pending |
| LQD | Lithium versus quetiapine in treatment resistant depression | ISRCTN16387615 | Pending |
| M4V | Mindfulness for Voices | ISRCTN74054823 | Published |
| MAAFA | Omega-3 fatty acids supplementation for adolescent boys with attention deficit hyperactivity disorder: a double-blind, randomized controlled trial | ISRCTN27741572 | Published |
| MAGSTAR | MAGnetic versus STAndard technique for sentinel node biopsy in breast cancer compared in a Randomised controlled trial | ISRCTN20200149 | No publication |
| MARQUE | The MARQUE project: Managing agitation and raising quality of life to improve agitation for people with dementia in care homes | ISRCTN96745365 | Published |
| MelaTools-SSM Trial | MelaTools skin self-monitoring study for primary care patients at higher risk of melanoma | ISRCTN16061621 | Published |
| MENOS | A trial of a non-medical treatment for menopausal symptoms in women with breast cancer | ISRCTN13771934 | Published |
| MIFCOG | Cortisol and memory in alcoholics: Mifepristone Study | ISRCTN54001953 | Published |
| MIMS | Pilot evaluation of distance delivered mindfulness based cognitive therapy for people affected by primary and secondary progressive multiple sclerosis | ISRCTN93263909 | Published |
| MINDEP | Understanding the molecular basis for the use of adjunctive anti-inflammatory treatment in treatment resistant depression: a stratified, randomised, placebo-controlled, experimental medicine study using minocycline | 2015-003413-26 | Published |
| MISTER | MInimal versus SpecialisT Equipment in the delivery of pulmonary Rehabilitation (MISTER): a randomised controlled trial | ISRCTN16196765 | Pending |
| MINDFULNESS FOR PARANOIA | Group mindfulness-based therapy for distressing persecutory delusions: A pilot study for a randomised controlled trial | ISRCTN17852603 | Published |
| MOLTO | Single arm feasibility of multi-maintenance olaparib after disease recurrence in participants with platinum sensitive BRCAm high grade serous ovarian cancer | NCT02855697 | Pending |
| MOSAIC | A Maudsley outpatient study of treatments for anorexia nervosa and related conditions | ISRCTN67720902 | Published |
| MOSAIC | A brief physiotherapist-led behaviour-change intervention to facilitate walking in older people with peripheral arterial disease: A randomised controlled trial | ISRCTN14501418 | Published |
| MOVEIT | A multi-centre randomised controlled trial comparing the effectiveness of enhanced motivational interviewing with usual care for reducing cardiovascular risk | ISRCTN84864870 | Published |
| MRINFORM | MR Perfusion Imaging to Guide Management of Patients With Stable Coronary Artery Disease | NCT01236807 | Published |
| MUST-IPF | MUscle STimulation in advanced Idiopathic Pulmonary Fibrosis: a randomised placebo-controlled feasibility trial (MUST-IPF) | NCT03499275 | Published |
| MYPS1 | Mycophenolate Treatment for Longstanding Complex Regional Pain Syndrome (MYPS I) | 2015-000263-14 | Published |
| N/A | Learning from COVID-19 related trial adaptations to inform efficient trial design-a sequential mixed methods study | N/A | Published |
| NAC | Effect of N-acetylcysteine on Brain Glutamate (NAC) | NCT02483130 | Published |
| NEAT | Naltrexone Enhanced Addiction Treatment (NEAT): A randomised controlled trial of the clinical and cost-effectiveness of extended-release naltrexone and oral naltrexone | 2013-002584-25 | Published |
| NERO | A randomised controlled trial of non-invasive ventilation (NIV) and hybrid inpatient-home based nutritional education and exercise rehabilitation programme versus NIV alone to reduce weight and increase physical activity in patients with obesity hypoventilation syndrome | NCT01483716 | Published |
| NeuroMooD | Comparing fMRI neurofeedback and neurostimulation treatments in self-blaming emotions in major depressive disorder – a pilot trial. | ISRCTN10526888 | Published |
| NEWMEDS2 | Neuroimaging effects of a single dose of modafinil on brain activation in patients with schizophrenia | ISRCTN66900787 | Published |
| NEWMEDS3 | Neuroimaging the effects of modafinil in healthy volunteers | ISRCTN36604066 | Published |
| NHF AECOPD | The role of nasal high-flow to reduce 30-day hospital readmissions following severe exacerbations of Chronic Obstructive Pulmonary Disease: a mixed-methods feasibility study | ISRCTN15949009 | Pending |
| NHSCHECK | NHS CHECK – Health & Experiences of staff working at NHS Trusts and Nightingale Hospitals | 2021-001279-18 | Published |
| NILVAD | A European multicenre double-blind placebo controlled phase III trial of nilvadipine in mild to moderate Alzheimer’s disease | 2012-002764-27 | Published |
| NOC | The NOC Study (Nitric Oxide in Cognition) | NCT02906553 | Published |
| NOSTUDY | The Effect of Nitric Oxide on Spatial Working Memory in Patients With Schizophrenia – Pilot Study | NCT02176044 | Published |
| NOURISHED | A Randomized Controlled Trial of Mentalization Based Therapy against Treatment as Usual in patients with both Eating Disorders and Borderline Personality Disorder | ISRCTN51304415 | Published |
| OPEN | Feasibility Randomized-Controlled Trial of Online Acceptance and Commitment Therapy for Painful Peripheral Neuropathy in People Living with HIV: The OPEN Feasibility Study | NCT03584412 | Published |
| OPEN | Olanzapine for young PEople with aNorexia nervosa (OPEN): an open-label feasibility study to test recruitment, treatment acceptance, adherence, safety, and outcome measures assessment and patients’ experience to prepare for a definitive randomised placebo-controlled trial | ISRCTN80075010 | Pending |
| OPTCARE ELDERLY | Optimising palliative care for older people in community settings | ISRCTN45837097 | Published |
| OPTCARE NEURO | Evaluation of the clinical and cost-effectiveness of Short-term Integrated Palliative Care Services (SIPC) to OPTimise CARE for people with advanced long-term Neurological conditions | ISRCTN18337380 | Published |
| OPTIMA | Optimising individualised prescribing with therapeutic drug Monitoring for Antipsychotics (OptIMA) 2: clinical pilot study of antipsychotic drug level monitoring | ISRCTN71305621 | Published |
| OPTYC | Online PTSD Treatment for Young People and Carers | ISRCTN16876240 | Pending |
| OUTSMART | Optimized TacrolimuS and MMF for HLA Antibodies after Renal Transplantation | ISRCTN46157828 | Published |
| OZDRY | A multicentre prospective randomised clinical trial comparing fixed dosing versus PRN dosing of intravitreal Ozurdex therapy for refractory diabetic macular oedema | 2012-003661-17 | Published |
| PACE | A randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise, as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy | ISRCTN54285094 | Published |
| PACEUP | Randomised controlled trial of a pedometer-based walking intervention with and without practice nurse support in primary care patients aged 45-74 years | ISRCTN98538934 | Published |
| PACT | A randomised controlled trial of brief physiotherapy informed by Acceptance and Commitment Therapy for chronic low back pain: the PACT study | ISRCTN95392287 | Published |
| PASTI | Parent-Administered Screen Time Intervention (PASTI): A 7-week three arm assessor blinded Feasibility and Pilot Randomised Controlled Trial, compared to Bedtime Box Intervention and No Intervention (1:1:1) in toddlers. | ISRCTN58249751 | Pending |
| PAVE | Paclitaxel assisted balloon Angioplasty of Venous stenosis in haEmodialysis access | ISRCTN14284759 | Published |
| PAZOFOS | A phase Ib and Randomised Phase II Trial of Pazopanib with or without Fosbretabulin in Advanced Recurrent Ovarian cancer | NCT02055690 | Published |
| PD-MIND | Parkinson’s Disease with Mild cognitive Impairment treated with Nicotinic agonist Drug | NCT04810104 | No publication |
| PD-RAD | A translational study investigating PD-L1 expression after radiotherapy for non-small cell lung cancer (NSCLC) | NCT03258788 | Pending |
| PETT | An external pilot randomised controlled trial to evaluate the performance of a research protocol to compare the Reconsolidation of Traumatic Memories (RTM) intervention with Trauma-Focussed CBT delivered by charities for the treatment of post-traumatic stress disorder (PTSD) in ex-military veterans | ISRCTN10314773 | Pending |
| PNE | Assessing the severity of short-term side-effects to a well-known tablet | ISRCTN47470030 | Published |
| POCD2 | Post-Operative Cognitive Decline 2 | NCT01743456 | Published |
| PollenLite_V | Intradermal allergen immunotherapy in adults with seasonal allergic rhinitis | ISRCTN78413121 | Published |
| POPPIES | Phase II B randomised placebo controlled trial of pre-operative Botulinum toxin type A in children with cerebral palsy for post-operative analgesia | NCT01437644 | Published |
| POST | Post-Deployment Health Screening of Members of the UK Armed Forces – ‘The Post Study’ | ISRCTN19965528 | Published |
| POST2 | Post-Deployment Health Screening of Members of the UK Armed Forces – ‘The Post Study’ (Phase 2) | ISRCTN19965528 | Published |
| POST3 | Post-Deployment Health Screening of Members of the UK Armed Forces – ‘The Post Study’ (Phase 3) | ISRCTN19965528 | Published |
| PRAISe | Positive reinforcement targeting abstinence in substance misuse | ISRCTN01591254 | Published |
| PRedSS | A Phase II Randomised Controlled Study of Oral Prednisolone in Early Diffuse Cutaneous Systemic Sclerosis | ISRCTN75313566 | Pending |
| PREHEAT | PREHEAT Trial – local heat preconditioning and wound healing | ISRCTN15744669 | Published |
| PRESERVE | How intensively should we treat blood pressure in established cerebral small vessel disease? | ISRCTN37694103 | Published |
| PROBIT-F | Prostaglandin insert (Propess) versus trans-cervical balloon catheter for out-patient labour induction: A randomised controlled trial of feasibility (PROBIT-F) | NCT03199820 | Published |
| PROFIT | A prospective randomised placebo controlled feasibility trial of Faecal Microbiota Transplantation in cirrhosis | NCT02862249 | Pending |
| PROMEX | Gut feeling: understanding the mechanisms underlying the antidepressant properties of probiotics | NCT03893162 | Published |
| PROMOTE | Dietary Protein and Skeletal Muscle in Older Twins – Targeting the Gut Microbiome to Overcome Anabolic Resistance: The PROMOTe Study | NCT04309292 | Pending |
| PSALTI | Efficacy of a Physiotherapy, Speech and Language Therapy Intervention for patients with chronic cough: a randomised controlled trial | ISRCTN73039760 | Published |
| PSALTIMC | Efficacy of a Physiotherapy, Speech and Language Therapy Intervention for patients with chronic cough: a randomised controlled trial | ISRCTN73039760 | Published |
| QOLITI | Quality Of LIfe Tool for IBD (QOLITI) | NCT02707068 | Pending |
| QUESTPR | Quadriceps neuromuscular electrical stimulation (NMES) as an adjunct to pulmonary rehabilitation (PR) in patients with COPD and quadriceps weakness – a randomised double-blind placebo-controlled trial | ISRCTN40579508 | Pending |
| RACEFIT | Reducing Acquisition of CMV through antenatal Education: A feasibility study to assess an educational intervention to prevent cytomegalovirus infection in pregnancy RACE-FIT | NCT03511274 | Published |
| RADI-CRT | A Prospective Randomised Controlled Trial of Cardiac Resynchronisation Therapy Guided by Invasive dP/dt: Radi-CRT Study | NCT01464502 | Pending |
| REACTCIPN | REACT-CIPN Study: a feasibility randomised controlled trial with process evaluation of a co-designed intervention for chemotherapy-induced peripheral neuropathy | ISRCTN10025993 | Pending |
| REACH-ASD | REACH-ASD Trial: A Randomised Controlled Trial of Psycho-Education and Acceptance & Commitment Therapy for Parents of Children recently diagnosed with ASD | ISRCTN45412843 | Pending |
| REDUCe | Palliative long-term abdominal drains versus repeated drainage in individuals with untreatable ascites due to advanced cirrhosis: a feasibility randomised controlled trial | ISRCTN30697116 | Published |
| REFOCUS | A cluster randomised controlled trial of recovery interventions within community based mental health teams | ISRCTN02507940 | Published |
| REHAB-EPO | Erythropoietin to facilitate stroke recovery | 2011-000123-33 | No publication |
| REST | Reducing Excess Salivation in clozapine Treatment: hyoscine for the treatment of clozapine induced nocturnal sialorrhoea | ISRCTN47146067 | Published |
| RESTORE | A randomised placebo-controlled trial investigating the effect of bilateral quadriceps neuromuscular electrical stimulation on exercise capacity in patients with severe COPD | ISRCTN15985261 | Published |
| RESTS | Treatment for insomnia in IAPT services | ISRCTN17064995 | Published |
| RESTUS | A randomised feasibility study examining daily sedation holds and nocturnal rest using neurally-adjusted ventilatory assist (NAVA) in patients at high risk of prolonged ventilatory failure during recovery from critical illness | NCT01826890 | Published |
| RETILASE | Efficacy and safety of retinal rejuvenation using Ellex 2RT laser in age-related maculopathy | ISRCTN87850962 | No publication |
| REZONE | Developing an app to help young people self-manage when feeling overwhelmed during lessons | ISRCTN13425994 | Published |
| RIOTT | Injectable versus oral opioid maintenance treatment for heroin addicts currently failing to benefit from standard treatment: a three way Randomised Controlled Trial (RCT) of injectable heroin versus injectable methadone versus oral methadone maintenance | ISRCTN01338071 | Published |
| RMC | A Pilot Randomised controlled trial of Methotrexate for Chronic Inflammatory Demyelinating Polyradiculoneuropathy | ISRCTN73774524 | Published |
| RTEANS | Real-time fMRI Neurofeedback as a novel neurotherapy for children with ADHD | ISRCTN14491589 | Published |
| SCIN | SCIN (Skin care intervention in nurses) Trial | ISRCTN53303171 | Published |
| SELF-BREATHE | A self-guided, internet-based intervention for patients with chronic breathlessness (SELF-BREATHE): feasibility randomised controlled trial | NCT04574050 | Pending |
| SHAPED-TF | Study of HAllucinations in Parkinson’s disease, Eye disease, and Dementia- Trial Feasibility | ISRCTN14435750 | Pending |
| SHE | Self-management migraine Headache Education: a pilot trial | ISRCTN53460881 | Published |
| SITADS | Pilot randomised controlled trial of SITAgliptin for Depressive Symptoms in type 2 diabetes | 2015-004527-32 | Published |
| SLOWMO | A randomised controlled trial to evaluate the outcomes and mechanisms of a novel digital reasoning intervention for persecutory delusions. | ISRCTN32448671 | Published |
| SITE | Supported discharge service versus in-patient treatment in adolescents admitted with psychiatric emergencies: a randomised controlled trial | ISRCTN82129964 | Published |
| SMILE | Self-Management education for adults with poorly controlled epilepsy | ISRCTN57937389 | Published |
| SnuggleDown | A clinical trial of the effectiveness of sensory weighted blankets in children with autism | ISRCTN92655217 | Published |
| SOFIA | Adapted Solution Focused brief therapy In post-stroke Aphasia (SOFIA trial): a feasibility study | NCT03245060 | Published |
| STAND | A randomised feasibility trial investigating Sativex® for the treatment of the Agitation & Aggression (A/A) in Alzheimer’s Dementia. | 2020-001056-17 | Pending |
| STAR | StereoTactic radiotherapy for wet Age-Related macular degeneration (STAR): A randomised, double-masked, sham-controlled, clinical trial comparing low-voltage X-ray irradiation with as needed bevacizumab, to as needed bevacizumab monotherapy. | NCT02243878 | Pending |
| STRIVE | Intravenous immunoglobulin (IVIg) treatment of transverse myelitis in adults and children | ISRCTN12127581 | Published |
| STRIVEHF | Standard Care Versus Triventricular Pacing in Heart Failure | NCT02529410 | Published |
| SUNSHINE | Psychoeducation in families of children with attention deficit hyperactivity disorder (ADHD) in the United Kingdom | ISRCTN26270684 | Published |
| SUPA | SUPA: Supporting UPtake and Adherence to antiretrovirals Applying the Medical Research Council guidance to evaluate an intervention to support uptake and adherence to antiretroviral therapy for HIV | ISRCTN35514212 | Pending |
| SUPERB | Adjustment with aphasia after stroke: Exploring the feasibility of a definitive phase III RCT for SUpporting wellbeing through PEeR Befriending (SUPERB) | NCT02947776 | Published |
| SWAN | Supporting women with postnatal weight management | ISRCTN39186148 | Published |
| SWL | Sleep, Wake and Light therapy for depression | NCT03405493 | Published |
| TESLAhome | Randomised controlled trial of domiciliary transcutaneous electrical stimulation in obstructive sleep apnoea | NCT03160456 | Pending |
| THRIL | Safety and Efficacy Study of Regulatory T Cell Therapy in Liver Transplant Patients | NCT02166177 | Published |
| TIARA | A sham-controlled randomised feasibility study of repetitive transcranial magnetic stimulation (rTMS) as an adjunct to treatment as usual in adults with severe and enduring anorexia nervosa (SE-AN) | ISRCTN14329415 | Published |
| TIBNFORCE | Tibia plateau pure and split depression fractures (AO 41-B2 and B3) stabilised with N-Force/iN3 bone cement +/- plate augmentation: A prospective single centre feasibility RCT comparing early (2 weeks) versus delayed (6 weeks) weight bearing | ISRCTN80008225 | Pending |
| TIES | Telephone delivered Incentives (verbal praise and small financial incentives) for encouraging individuals receiving methadone treatment to attend their pharmacy to take their medication: testing the feasibility of undertaking a future trial | ISRCTN58958179 | Published |
| TiMM | The role of apixaban, aspirin and enoxaparin as Thromboprophylaxis in patients newly diagnosed with Multiple Myeloma – an open label randomised control clinical trial – TiMM | 2015-002668-18 | Published |
| TITRATE | A pragmatic randomised controlled open trial of the effect of intensive management (IM) compared with standard care (SC) on remission rates at 12 months in rheumatoid arthritis patients with intermediate disease activity | ISRCTN70160382 | Published |
| TOHETI | A single centre randomised, nonblinded, prospective trial to evaluate the use of MRI as the initial imaging modality in the investigation of patients presenting with suspected scaphoid fracture | NCT02801149 | Published |
| TONICS feasibility | Trial of Neurostimulation In Conversion Symptoms (TONICS): A Randomised Controlled Trial (RCT) feasibility study of Transcranial Magnetic Stimulation (TMS) for conversion disorder with motor symptoms | ISRCTN51225587 | Published |
| ToTS | The Effect of THCV on THC | ISRCTN93423464 | Published |
| T-PAC | A prospective, randomised, single-centre feasibility study of combined autologous platelet-rich plasma and concentrated autologous bone marrow in adult patients with a fresh unilateral tibial diaphyseal fracture treated with either fine wire ring fixator device (Ilizarov) or reamed intramedullary nailing | NCT03100695 | Pending |
| TRESORA | The TRESORA study; a study to investigate T cell immune responses during the earliest stages of rheumatoid arthritis. | N/A | No publication |
| TRIANGLE | A multicentre randomised controlled trial to examine whether the addition of a patient and carer skills-sharing intervention improves long-term patient wellbeing following hospital treatment for anorexia nervosa. | ISRCTN14644379 | Pending |
| UANDI | Developing the evidence base to improve implementation and uptake of CBTp: A feasibility study adopting service user and clinician perspectives to shape a brief pre-CBTp interactive ‘informed choice’ intervention in the South East and London for patient benefit | ISRCTN53107879 | Pending |
| UMANC | A Phase I study of a novel synthetic polymer nerve conduit ‘Polynerve’ in participants with sensory digital nerve injury | NCT02970864 | Pending |
| UPBEAT | Case Management for depression and coronary heart disease | ISRCTN21615909 | Published |
| V-POPS | Evaluating the impact of preoperative Comprehensive Geriatric Assessment (CGA) to improve postoperative outcomes in older vascular surgical patients | ISRCTN23142588 | Published |
| VACIRISS | Pneumococcal Vaccination to accelerate Immune Recovery in Sepsis Survivors: randomized placebo-controlled trial | 2017-002236-17 | Pending |
| VISTFP | Vertebral artery Ischaemia Stenting Trial | ISRCTN95212240 | Published |
| VitaminK | The Additive effect of Vitamin K Supplementation and Bisphosphonate on Fracture Risk in Post-menopausal Osteoporosis | NCT01232647 | Published |
| VNeST | Feasibility and Acceptability Evaluation of Virtual Reality Supported Therapy for the Negative Symptoms of Psychosis | NCT03995420 | Published |
| WELLFOCUS | Pilot randomised controlled trial of a modified intervention to improve well-being in people with psychosis | ISRCTN04199273 | Published |
| WENDY | A cross-sectional study comparing the Whooley questions and Edinburgh postnatal depression scale against a diagnostic assessment in identifying depression in pregnancy | N/A | Published |
| WORSHIPII | Women Offenders Repeat Self-Harm Intervention Pilot II | ISRCTN18761534 | Published |
